Human beta-melanocyte-stimulating hormone revisited.

Y2-Melanocyte-Stimulating Hormone

Peptides of the pro-opiocortin class produce pronounced cardiovascular and natriuretic actions. We have investigated the acute cardiovascular effects of one of the most potent members of this class, y2-melanocyte stimulating hormone (y2-MSH), in rats. Pressor actions of y2MSH administered systemicaMy were eliminated by ganglionic blockade with chlorisondamine. Peripheral cholinergic blockade fa...

Desacetyl-α-melanocyte stimulating hormone and α-melanocyte stimulating hormone are required to regulate energy balance

OBJECTIVE Regulation of energy balance depends on pro-opiomelanocortin (POMC)-derived peptides and melanocortin-4 receptor (MC4R). Alpha-melanocyte stimulating hormone (α-MSH) is the predicted natural POMC-derived peptide that regulates energy balance. Desacetyl-α-MSH, the precursor for α-MSH, is present in brain and blood. Desacetyl-α-MSH is considered to be unimportant for regulating energy b...

A role for beta-melanocyte-stimulating hormone in human body-weight regulation.

Pro-opiomelanocortin (POMC) expressing neurons mediate the regulation of orexigenic drive by peripheral hormones such as leptin, cholecystokinin, ghrelin, and insulin. Most research effort has focused on alpha-melanocyte-stimulating hormone (alpha-MSH) as the predominant POMC-derived neuropeptide in the central regulation of human energy balance and body weight. Here we report a missense mutati...

-Melanocyte-Stimulating Hormone Inhibits Allergic Airway Inflammation

Beta-melanocyte stimulating hormone levels in subjects with hyperpigmentation associated with megaloblastic anemia.

By S. J. BAKER, V. I. MATHAN AND K. ABE H YPERPIGMENTATION OF THE SKIN in Indian patients with megaloblastic anemia appears to have been first documented by Cook.1 Studies from this unit suggested that this was often associated with vitamin B12 deficiency,2’3 though more recent studies following the introduction of folic acid assays, have shown that it can also occur in some cases of pure folat...